Van de Ven Brace Ends The Toffees' Run at New Stadium
The Dutch defender emerged as the first defender to score twice in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
Key points
Micky Van de Ven heads home two times in opening period
The home side's Jake O'Brien has goal disallowed after video check
Senegalese midfielder scores final goal in 89th minute
The defeat is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender scored twice as Spurs extended their unbeaten run in away games in the top division and handed Everton their first defeat at their new home.
The Toffees were unbeaten in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after more than a century at the conclusion of the previous campaign.
But Spurs captain Van de Ven pounced on two occasions from corners in the first half to place their strong form at jeopardy, and they were unable to turn it around before Pape Matar Sarr - set up by ex-Everton forward Richarlison - nodded in a final goal to put the game to bed.
Jake O'Brien believed he had levelled the tally five minutes after the defender's first goal, glancing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of opportunities, while Vicario made a succession of fine stops to guarantee the London club went five away games unbeaten in the Premier League.
But the video assistant referee intervened, instructing Craig Pawson to check the score on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
The win elevates the manager's team up to third in the division, five points off local foes and leaders Arsenal.
Everton stay in 14th position and are six points ahead of the drop zone.
Tottenham analysis: The defender excels in role at both ends of the field
Following a drab weekday display in the Champions League against Monaco, where they mustered a only attempts on goal, Frank opted for the French striker up front instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being substituted for Richarlison after 60 minutes on the field, but it emerged he proved unnecessary in the end.
Defender Van de Ven transformed into an attacking force to be feared.
Tottenham's first goal came from a well-worked corner routine, with the midfielder heading the ball back across the face of goal for an unmarked Van de Ven to head home.
And the captain - stepping up as skipper in Cristian Romero's absence - added his next goal in added time as he rose above Jordan Pickford to nod in.
The Dutchman was just as outstanding in defence, partnering effectively with his defensive colleague as the pair dealt excellently with the 34 crosses sent their way by Everton.
Toffees breakdown: Everton lacking finishing touch
Everton's recent stadium had been a fortress, but it appears the novelty may have faded slightly and supporters flocked to the exits after Sarr's final goal for Spurs.
The end in the team's unbeaten home run will not be a major concern for David Moyes, but their attacking woes will be.
Beto and the other striker - the Everton's pair of recognised centre-forwards - had netted only a single goal between them before Sunday's outing.
And they were unable to add to that miserable tally on a damp and dreary evening on in Liverpool.
The striker's form was summed up when he chose to bicycle-kick a clear chance from near the goal, despite having space and opportunity to reposition for a more conventional attempt that would have challenged Vicario.
Barry, too, failed to make an impact after coming on for Beto in the 65th minute.
It was not for a shortage of opportunity. Most of the home side's offensive moves came through the winger and Ndiaye, who relentlessly delivered dangerous balls into the Tottenham penalty area.
Upcoming fixtures for these two sides?
The Toffees: Moyes' men travel to the Stadium of Light in the top flight on early November at 8 PM.
Spurs: Spurs travel to St James' Park on late October for their next round Carabao Cup match against the Magpies.